About Breast Cancer

What is breast cancer?
Breast cancer occurs as a result of uncontrolled proliferation of cells in the breast by genetic mutation. These cells can jump to other organs of the body, ie they can metastasize.
Is breast cancer a hereditary disease?
Breast cancer alone is hereditary. Although it is not hereditary in -20 of patients, a few people in the family have been diagnosed with breast cancer before. In other words, p-75 patients in the family have no previous diagnosis of breast cancer. All women are at risk for breast cancer. One out of every 8 women has breast cancer.
Is there a specific target group / group of breast cancer?
Breast cancer can be seen in all women, but some factors are known to increase the risk of breast cancer. The incidence of breast cancer increases with age. The age at which menstruation begins before 12 years of age, entering late menopause (after 55 years of age), having no births or giving birth at late age (after 30 years of age), not breastfeeding, having people diagnosed with breast cancer in the family, alcohol and smoking, menopause post-obesity is an increased risk. Although the effect of nutrition on risk-raising is not clear, consuming too much red meat, consuming processed meat and eating too much fat can increase the risk. Vegetable and fruit weighted nutrition, physical activity is shown to reduce the risk of excessive.
Who should be screened for hereditary breast cancer?
Only those who are considered to be at high risk for hereditary breast cancer should be screened. Breast cancer developed in both breasts, the family has been diagnosed with both breast and ovarian cancer, having a family history of male breast cancer, having 2 or more breast cancer on the same side of the family (father or mother side), 1 or more people with ovarian cancer on the same side, first or second degree relatives of breast cancer under the age of 45 people who have been diagnosed with breast cancer suggests that may be hereditary. The most common genetic disorder in hereditary breast cancers is mutation in the BRCA-1 or BRCA-2 gene. Breast cancer develops in -85 of the people with this mutation and ovarian cancer develops in -45. Therefore, if a mutation is detected in BRCA-1 or BRCA-2 gene, preventive approaches are recommended.
The desire to screen for hereditary breast cancer was increased following the detection of this mutation in Angelina Jolie. However, this test is not recommended for everyone. It is recommended for people with a strong family history as in the case of Angelina Jolie.
What should be done to those at risk for hereditary breast cancer?
Preventive surgery, drug prevention and close follow-up are recommended. The most effective method is to reduce the risk by preventive surgeries. These include bilateral mastectomy, ie, the removal of the breast and ovarian ovaries against ovarian cancer. In mastectomy, the skin and nipple are protected and there is no aesthetic problem because silicone implants are placed during surgery. The removal of the ovaries is recommended after the age of 35-40 or after the desired number of children.
What are the symptoms of breast cancer?
The most common symptom of breast cancer is a painless mass in the breast. In addition, breast or skin shrinkage of the breast skin, reddening, edema or orange peel appearance and the armpit hand mass in the breast cancer should consider. Should these symptoms occur, they should consult a doctor immediately. The earlier the diagnosis is made, the easier the treatment.
Is screening and early detection possible in breast cancer?
Breast cancer screening is one of the recommended cancers. For screening for breast cancer in women at standard risk, annual mammography and annual medical examination should be performed after 40 years of age. From the age of 25, women are advised to examine their breasts and to have a medical examination every 1-3 years between 25-40 years of age.
What are the treatment methods?
Breast cancer is a treatable disease in case of early diagnosis and use of modern therapies. A successful treatment cannot be done by one branch. Multidisciplinary approach to success, ie, General Surgery, Medical Oncology, Radiation Oncology, Pathology, Radiology, Nuclear Medicine, such as many branches need to act jointly. For this purpose, patients should be discussed in the tumor council and treatment plans should be made.
The main treatment for early breast cancer is surgery. Radiotherapy, chemotherapy and hormonal treatment are applied to prevent recurrence after surgery. In other metastasized tumors, surgery is not performed and chemotherapy and / or hormonal treatment is applied.
Are there any targeted drugs other than chemotherapy in breast cancer?
Breast cancer consists of 4 different subgroups. These include target-directed agents such as trastuzumab, pertuzumab, T-DM1, which directly target the tumor in patients in the HER2 (cerb-B2) positive group. In hormone-sensitive breast cancers,